Prawitt,

Dirk,

Dr. rer. nat.

Anschrift:

Kinderklinik Uni-Mainz

Molekulargenetisches Labor

Obere Zahlbacher Str. 63

D-55131 Mainz

Tel.: +0049 (0)6131-39-33335

Fax.: +0049 (0)6131-39-30227

eMail: prawitt(at)molgen.medizin.uni-mainz.de

Forschungsinteressen:

 

Epigenetik

 

Beckwith-Wiedemann

 

Kanalgene (TRPM, OAT, ORCTL, KCNQ)

 

RNAi und knock-down Mausmodelle

 

Projektleiter:

 

SPP1129 Projekt PR 688/1-2

"Beckwith-Wiedemann syndrome and associated tumors - Identification of factors essential for imprinting mechanisms"

 

Identifizierung Schmerz relevanter genetischer Faktoren

 

Functional characterization of TRPM5

 

Chromosomal evolution

 

Schaltbares RNAi knock-down Mausmodell

 

Tumorgenetik

 

Genetik fruehkindlicher Epilepsien

 

Publikationen:

 

von Mach MA, Hengstler JG, Brulport M, Eberhardt M, Schormann W, Hermes M, Prawitt D, Zabel B, Grosche J, Reichenbach A, Muller B, Weilemann LS, Zulewski H.:

In vitro cultured islet-derived progenitor cells of human origin express human albumin in severe combined immunodeficiency mouse liver in vivo.

Stem Cells. 2004;22(7):1134-41.

 

Prawitt D, Brixel L, Spangenberg C, Eshkind L, Heck R, Oesch F, Zabel B, Bockamp E.:

RNAi knock-down mice: an emerging technology for post-genomic functional genetics.

Cytogenet Genome Res. 2004;105(2-4):412-21.

 

 

Prawitt D, Monteilh-Zoller MK, Brixel L, Spangenberg C, Zabel B, Fleig A, Penner R.:

TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15166-71.

 

Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX.:

A unified nomenclature for the superfamily of TRP cation channels.

Mol Cell. 2002 Feb;9(2):229-31.

 

Cichutek A, Brueckmann T, Seipel B, Hauser H, Schlaubitz S, Prawitt D, Hankeln T, Schmidt ER, Winterpacht A, Zabel BU.:

Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1).

Cytogenet Cell Genet. 2001;93(3-4):277-83.

 

Prawitt D, Enklaar T, Klemm G, Gartner B, Spangenberg C, Winterpacht A, Higgins M, Pelletier J, Zabel B.:

Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression.

Hum Mol Genet. 2000 Jan 22;9(2):203-16.

 

weiter Veröffentlichungen(PubMed)