Langenbeckstr. 1
Genomisches Imprinting Beckwith-Wiedemann Syndrom assoziierter Gene
Untersuchung allelspezifischer CpG-Methylierung, Bisulfit-Modifikation
Gewebespezifität des genomischen Imprinting in der murinen Entwicklung
Rolle des Ascl3-Gens in der Speicheldrüsenentwicklung
Genexpressionsregulation (Transkriptionskontrolle)
Asynchrone Replikation geprägter Gene
Enklaar T., Zabel B., Prawitt D. (2006)
Beckwith-Wiedemann syndrome: multiple molecular mechanisms
Expert.Rev.Mol.Med. (8) 17: 1-19
Prawitt D. & Enklaar T., Gärtner-Rupprecht B., Spangenberg C., Lausch E., Reutzel D., Fees S., Korzon M., Brozek I., Limon J., Housman DE., Pelletier J., Zabel B. (2005)
Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumor.
Nat Genet. 37 (8): 785-786
Prawitt D. & Enklaar T., Gärtner-Rupprecht B., Spangenberg C., Oswald M., Lausch E., Schmidtke P., Reutzel D., Fees S., Lucito R., Korzon M., Brozek I., Limon J., Housman DE., Pelletier J., Zabel B. (2005)
Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith–Wiedemann syndrome and Wilms’ tumor.
Proc.Nat.Acad.Sci. 102 (11): 4085-4090
Trost TM, Lausch EU, Fees SA, Schmitt S, Enklaar T, Reutzel D, Brixel LR, Schmidtke P, Maringer M, Schiffer IB, Heimerdinger CK, Hengstler JG, Fritz G, Bockamp EO, Prawitt D, Zabel BU, Spangenberg C. (2005)
Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells.
Cancer Res. 65 (3): 840-849
Bahn, A.; Prawitt, D.; Buttler, D.; Reid, G.; Enklaar, T.; Wolff, N. A.; Ebbinghaus, C.; Hillemann, A.; Schulten, H. J.; Gunawan, B.; Fuzesi, L.; Zabel, B., Burckhardt, G. (2000)
Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene.
Biochem. Biophys. Res. Commun. 275 (2): 623-630
Enklaar, T.; Eßwein, M.; Oswald, M.; Hilbert, K.; Winterpacht, A.; Higgins, M.; Zabel, B., Prawitt, D. (2000)
Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family.
Genomics 67 (2): 179-187
Kraemer, C.; Enklaar, T.; Zabel, B., Schmidt, E. R. (2000)
Mapping and structure of DMXL1, a human homologue of the DmX gene from Drosophila melanogaster coding for a WD repeat protein.
Genomics 64 (1): 97-101
Prawitt, D.; Enklaar, T.; Klemm, G.; Gärtner, B.; Spangenberg, C.; Winterpacht, A.; Higgins, M.; Pelletier, J., Zabel, B. (2000)
Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression.
Hum. Mol. Genet. 9 (2): 203-216.
Winterpacht, A.; Endele, S.; Enklaar, T.; Fuhry, M., Zabel, B. (1996)
Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3.
Cytogenet. Cell Genet. 75(2-3): 132-135
Mitarbeiter 